pentobarbital will decrease the extent or impact of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will reduce the extent or impact of etravirine by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep an eye on.Just after halting a CYP3A4 inducer, as the effects from the inducer